Two common insomnia medicine on the market include quviviq (daridorexant) and zolpidem, but there is a big difference between them in terms of mechanism, adverse effects and how long they can be used. This blog discusses the comparison between Quviviq vs zolpidem, reasons why some individuals find it difficult to sleep after taking zolpidem as well as explaining the status of zolpidem in the UK.
Mechanisms and Effects of Quviviq vs Zolpidem.
Quviviq is a dual orexin receptor antagonist- the medicine decreases wakefulness by acting on the orexin system that increases arousal in the brain. This is a mechanism that assists in maintaining natural sleep architecture allowing the user to fall asleep easily without causing serious inconvenience to the REM sleep or memory formation. Quviviq recommended patients with long-term insomnia who need a long term one with minimal cognitive and aftereffects.
Zolpidem, or Ambien (US), Stilnoct (UK) is a type of Z-med, which boosts GABA activity leading to global silencing of brain activity and resulting in sleep. Zolpidem is very efficient in that it helps a person to fall asleep quickly. But it can cause disruption of the structure of sleep, such as a decrease in REM sleep.
And an increased risk of dependence or tolerance with long-term use as well as leading to next-day drowsiness. Cognitive impairment, and increased likelihood of dependence or tolerance.
Unexpected Wakeup After Zolpidem: What Is the Reason?
Most of the users feel why am I unable to sleep after taking zolpidem; a low percentage of users have the opposite effect in which they feel stimulated or cannot sleep. This may be because of unique neurochemical action.
Zolpidem inhibits the activity of inhibitory neurons through GABA. And at times it may result in the excitatory neuron becoming more active and thus interfering with sleep initiation.
The determinants that likely to predispose the risk include alcohol consumption.
Moreover, there patients who become tolerant to the long-term use of the medication. All this reduces its effectiveness and leads to withdrawal insomnia.
Other therapeutic side effects of zolpidem may be sleepwalking. Inappropriate night behavior, and hallucination, also known as the “Ambien Zombie effects.
In case there is sleeplessness or agitation after taking zolpidem. Then the use should discontinue and a doctor consulte on alternative treatment such as Quviviq or sleep hygiene consultation.
Access and Guidelines Zolpidem in the UK.
Zolpidem (Stilnoct) another prescription medication use the UK to treat insomnia on a short-term basis. GPS usually prescribe to a maximum of 4 weeks at a dosage of 10mg a night. Zolpidem can at the internet pharmacies and requires the consultation of the doctor.
Patients should use zolpidem only on the condition of being able to get 7-8 hours of continuous sleep and should not take it with alcohol or sedatives. We will not suggest it for long-term use. Newer agents such as Quviviq or non-med methods might be more desirable as a method of sustainable management of insomnia.
Conclusion
Quviviq is also unusual in its chronic insomnia, where its action is targeted and no in-depth research has been conducted on the overdependence on daytime activities. Whereas zolpidem is still effective but with increased risks of tolerance, undoing response, and memory loss.
One who is not able to sleep following the intake of zolpidem is advised to consult a doctor in order to see the possibility of alternative treatments. Zolpidem is prescribed in the UK but it is controlled by sales on the internet. But it should always be under the appropriate medical guidance.
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